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Treatments Under Development
Here you will find a list of current treatments under development:
| Brand Name: | Actimid |
| Generic Name: | pomalidomide |
| Code Name: | CC-4047 |
| Company: | Celgene |
| FDA Clinical Phase: | 1/2 |
Description
Actimid is an immunomodulatory agent (a drug that affects the immune system) that encourages a patient’s immune system to attack and destroy myeloma cells. Actimid is a chemical analogue, or closely related “cousin,” of the drug thalidomide (Thalomid), which is already FDA-approved for multiple myeloma treatment. Like thalidomide, Actimid appears to function through multiple pathways to…
| Brand Name: | Afinitor |
| Generic Name: | everolimus |
| Code Name: | RAD001 |
| Company: | Novartis |
| FDA Clinical Phase: | 1/2 |
Description:
Afinitor was approved by the FDA in March 2009 for the treatment of advanced renal cell carcinoma, but it is currently also being studied in multiple myeloma. It works by inhibiting an enzyme called mammalian target of rapamycin (mTOR). The enzyme mTOR has a role in cell growth and is associated with tumor progression. Afinitor…
| Brand Name: | Aplidin |
| Generic Name: | plitidepsin |
| Code Name: | |
| Company: | PharmaMar, SA |
| FDA Clinical Phase: | 2 |
Description:
Aplidin is derived from a compound found in tunicates which shows promise in shrinking tumors. The specific marine organism is Aplidium albicans.
Clinical Trials:
There are currently no open clinical trials studying Aplidin for multiple myeloma.
Official website for Aplidin: http://www.pharmamar.com/en/pipeline/aplidin.cfm
Source: Wikipedia, Aplidine, http://en.wikipedia.org/wiki/Aplidine (as of November 14, 2009)
…
| Brand Name: | Atiprimod |
| Generic Name: | azaspirane |
| Code Name: | SK&F106615 |
| Company: | Callisto Pharmaceuticals |
| FDA Clinical Phase: | 1/2 |
Description:
A substance being studied in the treatment of certain multiple myelomas and other advanced cancers. Atiprimod may block the growth of tumors and the growth of new blood vessels that tumors need to grow. Atiprimod is a type of signal transduction inhibitor.
Clinical Trials:
Currently, there are no open clinical trials studing Atiprimod for multiple myeloma.
Source: NCI Cancer…
| Brand Name: | Avastin |
| Generic Name: | bevacizumab |
| Code Name: | rhuMAb-VEGF |
| Company: | Genentech Inc. |
| FDA Clinical Phase: | 2 |
Description:
Avastin is a monoclonal antibody used in the treatment of colorectal cancer that has spread. It is also being studied in the treatment of other types of cancer. Avastin binds to vascular endothelial growth factor (VEGF) and may stop the growth of new blood vessels needed for tumors to grow. It is a type…
| Brand Name: | Bexxar |
| Generic Name: | iodine I 131 tositumomab |
| Code Name: | |
| Company: | GlaxoSmithKline |
| FDA Clinical Phase: | 2 |
Description:
Bexxar is a monoclonal antibody to which radioactive iodine 131 is attached, which targets a protein called CD20 found on the surface of a variety of B-cells, including lymphoma cells, and some myeloma cells. The radioactive iodine attached to the antibody delivers radiation directly to these cells which works to harm or…