Articles tagged with: Stem Cell Transplant

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[ by and | Aug 21, 2013 4:19 pm | Comments Off ]
Transplantation With Stem Cells Collected After An Initial Transplant May Increase A Myeloma Patient's Risk Of Developing MDS

Results from a recent study indicate that collecting more stem cells prior to a myeloma patient’s first transplant may be beneficial for future trans­plants.

Specifically, relapsed patients who received a second transplant with cells that had been collected prior to their first transplant, rather than those collected following the first transplant, had a lower risk of later developing myelodysplastic syndromes (MDS).

MDS is a group of blood disorders marked by ineffective production of blood cells.  MDS often progresses to acute myeloid leukemia, an ag­gres­sive blood cancer in which the body …

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[ by and | Aug 16, 2013 3:11 pm | 3 Comments ]
Early Or Late Stem Cell Transplantation For Myeloma? New Study Finds Both Strategies Yield Similar Overall Survival

Results from a retrospective study show that delaying stem cell trans­plan­ta­tion following initial therapy may result in shorter progression-free survival following transplantation compared to transplantation soon after diagnosis.

However, the results also show that the timing of transplantation does not significantly impact overall survival.

The median progression-free survival after transplantation was 28 months for those who underwent early transplantation (within 12 months of diagnosis) compared to 18 months for those who underwent delayed transplantation (more than 12 months after diagnosis).  This difference was not statistically significant, but the study investigators …

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Opinion»

[ by | Aug 1, 2013 1:14 pm | 38 Comments ]
Pat’s Place: Risk Versus Reward When Considering A Stem Cell Transplant

In last month’s column, I wrote about how much my perspective on myeloma therapy has changed over the past six years since my diagnosis.  In a nutshell, I’m more willing to try new things and endure troubling side effects now than I was back when I was still a “rookie.”

My attitude about stem cell transplants is a perfect example of this.  I look at stem cell transplants differently now – both allogeneic transplants (using donor stem cells) and autologous transplants (using my own stem cells).  Not only would …

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[ by | Jul 15, 2013 2:28 pm | One Comment ]

Revlimid Plus Dexamethasone Extends Progression-Free Survival In Newly Diagnosed Multiple Myeloma Patients – Results of a large international Phase 3 trial show that Revlimid (lenalidomide) plus dexamethasone (Decadron) ex­tends progression-free survival in newly diagnosed multiple myeloma patients who are not eligible for autologous stem cell transplantation, compared to treat­ment with melphalan (Alkeran), prednisone, and thalidomide (Thalomid). Based on these findings, Celgene, the manufacturer of Revlimid, will start the pro­cess of applying for approval of Revlimid as frontline treat­ment in the United States, Europe, and other countries. Although Celgene is widely used in the U.S. for the treatment of newly diagnosed myeloma patients, it is not officially approved for that use in the U.S. or any other country.  For more information, please see the related press release from Celgene.

Order Of Velcade And Revlimid Treatment May Not Matter In Treating Myeloma – Results from a recent retrospective study indicate that multiple myeloma patients benefit equally whether they are treated with Velcade (bortezomib) before Revlimid, or vice versa. However, patients with kidney disease tend to benefit from earlier use of Velcade-based therapies. Both Revlimid- and Velcade-based therapies have become common treatment options for myeloma patients. The investigators of this study were interested in de­ter­min­ing whether one drug should be given before the other. In their analysis, which was based on data for 208 myeloma patients treated between 2003 and 20089, the authors adjusted for a number of potential biases, such as patient age, number of previous therapies, and whether or not a patient had received a stem cell transplant.  The researchers found no significant difference in median overall survival between patients who received Revlimid first versus those who received Velcade first. For more information, please refer to the study in the journal Leukemia Research (abstract).

Unrelated Donor Stem Cell Transplant May Be An Under-Utilized Treatment Option For Myeloma – Find­ings from a retrospective study suggest that donor stem cell transplants using cells from unrelated donors may be underutilized for myeloma patients, particularly older myeloma patients. Specifically, the researchers found that only 11 percent of the myeloma patients they estimated to be eligible for an unrelated donor trans­plant actually underwent the procedure. Reasons for not undergoing a transplant included not being referred to a transplant center, worsening health condition of the patient, a prolonged search for a suitable donor, and financial issues. Donor (allogeneic) stem cell transplants involve infusing a patient with donor stem cells after high-dose chemotherapy. While the procedure has the potential to cure myeloma, it also is often accompanied by serious complications, including graft-versus-host-disease (GVHD), in which donor im­mune system cells recognize the patient's cells as foreign and attack them. For more information, please re­fer to the study in the journal Biology of Blood and Marrow Transplantation (ab­stract).

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[ by | Jul 3, 2013 4:48 pm | One Comment ]

Hybrid Drugs Based On Thalidomide And Curcumin May Be A Future Treat­ment Option For Myeloma Patients – Results from a recent preclinical study indicate that hybrid molecules combining chemical structures from thal­ido­mide (Thalomid) and curcumin may be potential treatments for multiple myeloma. Specifically, the investigators found that two particular hybrid mole­cules were effective in killing myeloma cells and were safer than either drug alone. Cur­cu­min is the major active compound in turmeric, a popular Indian spice. Several early-stage studies have investigated curcumin's potential as a myeloma treat­ment (see related Beacon news articles). Ac­cord­ing to the re­search­ers, hybrid drug therapy, which involves combining elements from two or more drugs into one molecule, is a promising treatment option for myeloma because it may be be safer and associated with a reduced risk of developing drug resistance. For more information, please refer to the study in the journal Organic and Bimolecular Chemistry (abstract).

Tandem Autologous Stem Cell Transplants May Not Cause Serious Heart Problems – Results from a small, retrospective Slovenian study suggest that two back-to-back, or tandem, autologous stem cell trans­plants (using the patient’s own cells) may not cause serious heart problems in the long-term. The study in­cluded 12 patients, each of whom received cyclo­phos­pha­mide (Cytoxan) for stem cell mobiliza­tion, and then high-dose chemotherapy with melphalan (Alkeran) prior to each transplant.  None of the patients de­vel­oped critical heart issues six years after their tandem transplant.  However, the re­search­ers did detect some signs of heart damage in the more detailed tests they carried out.  Thus, the authors recommend long-term follow-up studies with tandem transplant patients, in part because of the increasing life expectancy of myeloma patients. For more information, please see the study in journal Radiology and Oncology (full-text).

Methotrexate-Cytarabine Combination May Be Useful For Stem Cell Remobilization – Results from a small study conducted in South Korea indicate that a combination of high-dose methotrexate and cytarabine (Cyto­sar-U) plus granulocyte colony-stimulating factor (G-CSF) may be a useful alternative for stem cell mobili­za­tion.  Cytarabine is an older chemo­thera­py drug which has been used in the treatment of certain leukemias and lymphomas.  Methotrexate also is an older drug, which has been used in high doses as a chemo­thera­py agent, and in low doses to treat various auto­immune dis­orders, including rheuma­toid arthritis.  The Ko­re­an study included eight patients who had previously failed to mobilize sufficient stem cells using regimens including G-CSF and conventional chemo­therapy agents.  Of those eight patients, all but one were able to mobilize a sufficient number of stem cells using the methotrexate-cytarabine-G-CSF combination. The re­search­ers point out that larger studies are necessary to confirm their findings. For more information, please refer to the study in the journal Transfusion (abstract).

Donated, Virus-Specific White Blood Cells Effective For Severe Viral Infections After Donor Trans­plan­ta­tion – Results of a recent study show that donated t-cells, a type of white blood cell, can be used to treat severe viral infections in patients who have undergone allogeneic (donor) stem cell trans­plan­ta­tion.  During the study, virus-specific t-cells were collected from individuals who were immune to certain viral infections. The do­nated t-cells were then used to treat a total of 50 patients who had undergone a donor stem cell trans­plant and then developed a severe viral in­fec­tion.  In 74 percent of the cases, the donated t-cell treat­ment led to either a partial or complete elimination of the viral infection.  According to the researchers, the treatment was well tolerated; there were no infusion-related side effects, and only 4 percent of the patients developed graft-versus-host disease after the t-cell infusions.  Graft-versus-host disease is a com­pli­ca­tion that arises when donor cells identify the recipient cells as foreign and attack them. For more information, please the study in the journal Blood (full text).