Yesterday, the third day of the American Society of Hematology (ASH) 2011 Annual Meeting in San Diego, was the busiest day of the meeting for people interested in multiple myeloma.  Myeloma-related presentations filled the entire morning and afternoon, and sometimes there were even multiple relevant presentations going on simultaneously.

The morning presentations about therapies combining current myeloma drugs will be covered in this update.  Morning presentations about potential new myeloma therapies were covered in an update published earlier today, and presentations from the rest of the day will be…

Results from a number of multiple myeloma studies were presented yesterday during the second day of the American Society of Hematology (ASH) 2011 annual meeting in San Diego.

Predicting Response To Immunomodulatory Drugs

During an oral presentation and a poster presentation yesterday, researchers discussed the role of the protein cereblon in the treatment of myeloma.  Results from one study (abstract) in myeloma cell lines suggested that cereblon plays a key role in whether multiple myeloma patients respond to the immunomodulatory drugs Revlimid (lenalidomide) and pomalidomide.  Another study…

Results of a recent study show that newly diagnosed multiple myeloma patients initially treated with a combination of cyclophosphamide, Velcade, and dexamethasone have better response rates and less severe side effects than patients treated with Revlimid-dexamethasone or cyclophosphamide-Revlimid-dexamethasone.

The survival outcomes for the patients treated with cyclophosphamide, Velcade, and dexamethasone also are promising.

However, the difference in survival rates between the three treatment regimens is not statistically significant.

This is partly because “the numbers [of patients in the study] were too small to show differences in survival,” explained Dr. Craig Reeder…

A group of French myeloma specialists recently published a review of treatment strategies for multiple myeloma patients who have relapsed or become resistant to previous therapies.

This Beacon article, the second in a two-part series, summarizes the review’s insights into issues that need to be considered when choosing among relapse treatment options

Part 1 summarizes the review’s perspectives on the use of novel agents in the treatment of relapsed and refractory myeloma.  

According to the authors of the review, the goal at relapse is to select a treatment regimen…

A group of French myeloma specialists recently published a review of treatment strategies for multiple myeloma patients who have relapsed or become resistant to previous therapies.

This Beacon article, the first in a two-part series, summarizes the review’s perspectives on the use of novel agents in the treatment of relapsed and refractory myeloma.  

A second Beacon article will look at the review’s insights into issues that need to be considered when choosing among relapse treatment options.

The authors of the recent review begin their discussion by noting how use…