Articles tagged with: Carfilzomib

News»

[ by | Aug 17, 2014 4:10 pm | 5 Comments ]
Kyprolis Fails To Provide Overall Survival Benefit In FOCUS Phase 3 Trial

Amgen has given a first glimpse of key results from its FOCUS Phase 3 clinical trial testing Kyprolis in relapsed and refractory multiple myeloma patients.

The company reported this past Wednesday that Kyprolis did not provide an overall survival advantage in the trial, which is being con­ducted out­side the United States.

In addition, the company noted that patients treated with Kyprolis during the trial experienced more kidney-related side effects than patients who were not treated with the drug.

Up until recently, the primary significance of the FOCUS trial would have …

Read the full story »

News»

[ by | Aug 4, 2014 6:51 pm | 16 Comments ]
Kyprolis Succeeds In Phase 3 Relapsed Multiple Myeloma Trial – Approval Filings Planned For Europe And Other Countries

Amgen this morning announced initial results of its Phase 3 “ASPIRE” trial com­par­ing Kyprolis-Revlimid-dex­a­meth­a­sone to Revlimid-dex­a­meth­a­sone in pa­tients with relapsed multiple myeloma.

Patients in the trial who received the Kyprolis-Revlimid-dex­a­meth­a­sone com­bi­na­tion (KRd) had significantly longer progression-free survival (26.3 months) than patients who received only Revlimid and dex­a­meth­a­sone (Rd) (17.6 months).

There was also a trend in the results toward improved overall survival among the patients who received KRd versus those who did not. How­ever, the difference is not yet statistically significant.

The results of the trial are important for two …

Read the full story »

News»

[ by | Jun 14, 2014 9:59 pm | One Comment ]
ASCO 2014 Multiple Myeloma Update – Day Four: Poster Presentations

This year’s American Society of Clinical Oncology (ASCO) annual meeting in Chicago ended last Tuesday.

The day before the meeting ended was the busiest day at the meeting with re­gard to myeloma research.  It featured a session of oral pre­sen­ta­tions in the morn­ing and a poster session in the afternoon. In addition, an education ses­sion was held in the afternoon that included one myeloma-related talk, given by Dr. Leif Bergsagel of the Mayo Clinic, about progress in the treatment of mul­ti­ple myeloma (article in the ASCO 2014 Edu­ca­tional Book). …

Read the full story »

News»

[ by | May 31, 2014 9:17 pm | 3 Comments ]
ASCO 2014 Multiple Myeloma Update – Day One

This year’s American Society of Clinical Oncology (ASCO) annual meeting began yester­day morning in Chicago and will run through Tuesday.

Myeloma-related presentations were made during two sessions yes­ter­day.

One session was designed to better educate physicians about per­son­al­ized therapy for elderly patients with lymphoid malignancies. During that session, Dr. Tanya Marya Wildes from the Washington University School of Medicine in St. Louis talked about how to navigate treatment options for older multiple myeloma patients.

The key myeloma-related research presented yesterday was made public during a poster session in the afternoon …

Read the full story »

News»

[ by | Mar 1, 2014 5:56 pm | 2 Comments ]
The Top Myeloma Research Of 2013

The year 2013 is likely to be remembered as a very good year when it comes to research related to multiple myeloma.

Previous years have witnessed research shedding new light on existing my­e­lo­ma therapies, as well as additional research about potential new therapies.

But, in the past, most of the important new therapies that were being researched were from existing classes of therapy, making them less likely to offer dramatic im­prove­ments in the treat­ment of the disease.

In 2013, not only was there more research about existing therapies, and more …

Read the full story »