Articles tagged with: Bortezomib
Results of a recent small Australian study suggest that multiple myeloma patients who relapse within 12 months of their first transplant may benefit from a second transplant with melphalan plus Velcade as the intensive therapy immediately prior to their second transplant.
Based on these findings, the investigators propose that this regimen be further explored in the context of back-to-back stem cell transplants in patients who are at risk for an early relapse.
The study investigators note, however, that their study was small and retrospective in nature, and that a follow-up …
Results from an Italian Phase 1/2 trial show that a combination therapy consisting of lower doses of Velcade, melphalan, and prednisone may be an effective and safe salvage therapy for older multiple myeloma patients.
Over half of the patients in the trial responded to the treatment, and according to the study investigators, the treatment was well tolerated, making it a viable treatment option for older myeloma patients.
The results of a recent retrospective study suggest that treatment with Velcade or thalidomide may increase multiple myeloma patients’ risk of developing abnormal lung function.
Specifically, patients treated with Velcade (bortezomib)-based regimens were twice as likely to develop lung obstruction, and those treated with thalidomide (Thalomid)-based regimens were twice as likely to develop lung restriction.
However, the study investigators note that their study did not include information about lung disease patients may have had before their myeloma therapy. The researchers acknowledge that this could affect the interpretation of …
Myeloma Patients May Be At Higher Risk For Restless Legs Syndrome – Results from a recent Turkish study show that restless legs syndrome occurs more frequently in multiple myeloma patients than in healthy adults. Restless legs syndrome is a condition characterized by uncomfortable sensations in the legs and an uncontrollable urge to move them, often leading to sleep deprivation. In this study, 18 percent of myeloma patients had restless legs syndrome, compared to 3 percent in the healthy population. Multiple myeloma patients with restless legs syndrome had higher levels of depression and anxiety and a poorer quality of life compared to those without the condition. The researchers conclude that targeting restless legs syndrome may improve overall health outcomes in myeloma patients. For more information, please see the study in the Journal of Clinical Medicine Research (abstract).
Ibrutinib Enhances Anti-Myeloma Activity Of Velcade And Revlimid – Results from a recent preclinical study show that ibrutinib (PCI-32765) may enhance the activity of Velcade (bortezomib) plus Revlimid (lenalidomide). Ibrutinib, which is being developed by biotech company Pharmacyclics in cooperation with Johnson & Johnson, blocks a protein called Bruton’s tyrosine kinase (Btk). Btk is found in antibody-producing cells and in cells that break down bone tissue. Ibrutinib is currently being investigated as a potential treatment for a number of different blood cancers, including multiple myeloma. The study researchers believe their data warrants further investigation of ibrutinib as part of a combination drug therapy for multiple myeloma. For more information, please see the study in Cellular Signalling (abstract).
Phase 1/2 Clinical Trial To Study PRLX 93936 In Relapsed And Refractory Multiple Myeloma Patients – Prolexys Pharmaceuticals is starting a Phase 1/2 clinical trial of PRLX 93936 in relapsed and refractory myeloma patients. PRLX 93936 is a small-molecule anti-cancer treatment that targets the RAS protein. Specifically, researchers are seeking to determine patient response to and the maximum tolerated dose of PRLX 93936. Patients must have received two or more prior treatment regimens, including a proteasome inhibitor (such as Velcade) and/or an immunomodulatory agent (such as Revlimid) to be eligible for the study. For more information, please see the clinical trial description.
Results from a small, retrospective study indicate that combination therapy with Velcade, cyclophosphamide, and dexamethasone may be effective in newly diagnosed myeloma patients with kidney damage.
The findings, discussed in a letter to the editor of the European Journal of Haematology, show that kidney impairment did not worsen in any patients who received the three-drug treatment.
The study investigators also note that side effects were manageable, but recommend further research of the three-drug therapy to determine its safety as a long-term treatment option.
Kidney impairment is a common myeloma-related complication. …