Comments on: Revlimid http://www.myelomabeacon.com/resources/2008/10/15/revlimid/ Multiple myeloma news, resources, and online forums for patients, caregivers, and others interested in multiple myeloma. Fri, 10 Feb 2012 06:31:17 +0000 hourly 1 By: francesco http://www.myelomabeacon.com/resources/2008/10/15/revlimid/comment-page-1/#comment-32064 francesco Sat, 26 Feb 2011 18:24:34 +0000 http://www.myelomabeacon.com/?p=975#comment-32064 Hi, I followed a Rev-Dex induction therapy last summer (May - Aug: Rev at 25 mg/day, 21 days out of each 28 days - and Dex at 40 mg/day once a week). During that I had NO Peripheral Neuropathy (PN). One month after induction, I had Cyclophosphamide (CY) for Stem Cells mobilization: it was then that I had PN for the first time in my life: at the fingers of a single hand, they ceased after about 4 hours, not painful. About 1 month and a half later I underwent my first ASCT (with Melphalan (200 mg/m2)). It was then that I had very clear PN at both my heels for 2 or 3 days. Unfortunately from then on (3 months have passed now) I am experiencing PN everyday: numbness and tingling (and sometime loss of touch) at the fingers of both hands every morning at wake up or when I hold my arm bent for some minute. What can the origin of this (so far mild) PN be ? Can it be Revlimid even if I had it more than 5 months ago for the last time ? Why I had the only 2 acute episodes of PN when I had chemos (CY and Melphalan) ? Doctors have not given me a clear opinion. Many thanks. Francesco Hi,
I followed a Rev-Dex induction therapy last summer (May – Aug:
Rev at 25 mg/day, 21 days out of each 28 days – and Dex at 40 mg/day once a week). During that I had NO Peripheral Neuropathy (PN).
One month after induction, I had Cyclophosphamide (CY) for Stem Cells mobilization: it was then that I had PN for the first time in my life: at the fingers of a single hand, they ceased after about 4 hours, not painful.
About 1 month and a half later I underwent my first ASCT (with Melphalan (200 mg/m2)). It was then that I had very clear PN at both my heels for 2 or 3 days.
Unfortunately from then on (3 months have passed now) I am experiencing PN everyday: numbness and tingling (and sometime loss of touch) at the fingers of both hands every morning at wake up or when I hold my arm bent for some minute.

What can the origin of this (so far mild) PN be ? Can it be Revlimid
even if I had it more than 5 months ago for the last time ?
Why I had the only 2 acute episodes of PN when I had chemos (CY and Melphalan) ?
Doctors have not given me a clear opinion.

Many thanks.
Francesco

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