Combined data from two recent Phase 1 clinical trials suggest that twice-weekly marizomib, with or without low-dose dexamethasone, may be effective for patients with relapsed or refractory multiple myeloma.

Dr. David Vesole from the John Theurer Cancer Center in Hackensack, New Jersey, who was not involved in the study, described marizomib as having “modest activity in relapsed/refractory myeloma.”

Dr. Paul Richardson from the Dana-Farber Cancer Institute in Boston presented the results at the American Society of Hematology (ASH) annual meeting in San Diego last month.

Marizomib (NPI-0052), which is being…

Throughout 2011, The Myeloma Beacon published many articles that serve as helpful resources for multiple myeloma patients and others interested in myeloma.

These articles included interviews with, columns written by, and summaries of treatment guidelines from leading myeloma experts.  They also included articles providing helpful information about rare types of myeloma and exciting new treatment options that are being studied in clinical trials.

All these articles were published in addition to the Beacon’s coverage of the latest myeloma-related news and research results, and in addition to the Beacon’s columns written…

How do you keep yourself from constantly thinking about this disease?

I realize I’m very fortunate to be healthy (except for the fact I have cancer) and don’t have any of the physical issues associated with multiple myeloma that so many others have to deal with.  Consequently, however, the battle for me tends to be mostly psychological.

For me, that’s not necessarily a good thing.

I have degrees in electrical engineering and mathematics, and as you might imagine, I’m a geek, I’m a problem solver, and I will obsess on…

The results of a small Phase 1 clinical trial demonstrate that BT-062, a new drug specifically targeting multiple myeloma cells, shows activity and is tolerable in heavily pretreated multiple myeloma patients.

Dr. Sundar Jagannath of the Mount Sinai Medical Center in New York City presented the results at the 2011 American Society of Hematology (ASH) conference in San Diego last month.

Based on the favorable safety and activity of BT-062, a Phase 1/2 clinical trial has been initiated and is currently recruiting patients. It will use a more…

Interim results from a Phase 2 study show that panobinostat may be clinically beneficial for certain multiple myeloma patients with advanced disease.

In the study, patients who had relapsed and were no longer responsive to Velcade-based treatments received panobinostat in combination with Velcade and dexamethasone.

Although the results generally are being viewed as favorable, “It is hard to interpret them because you don’t really know how the patients would have done with just Velcade and dexamethasone alone,” explained Dr. Leif Bergsagel, a myeloma specialist from the Mayo Clinic in Arizona,…