Comments on: Higher Quality Response To Revlimid-Dexamethasone Combination Yields Better Prognosis For Relapsed And Refractory Multiple Myeloma Patients http://www.myelomabeacon.com/news/2010/07/28/higher-quality-response-to-revlimid-dexamethasone-combination-yields-better-prognosis-for-relapsed-and-refractory-multiple-myeloma-patients/ Multiple myeloma news, resources, and online forums for patients, caregivers, and others interested in multiple myeloma. Sat, 11 Feb 2012 17:24:22 +0000 hourly 1 By: maureen napoli http://www.myelomabeacon.com/news/2010/07/28/higher-quality-response-to-revlimid-dexamethasone-combination-yields-better-prognosis-for-relapsed-and-refractory-multiple-myeloma-patients/comment-page-1/#comment-12417 maureen napoli Sat, 31 Jul 2010 14:12:55 +0000 http://www.myelomabeacon.com/?p=9487#comment-12417 My husband has nonsecretory MM, after stem cell, then thalidomide plus prednisolone, has relapsed & just started Revlimid plus dex. Wondering if anyone with non-sec MM is going down this track. Maureen My husband has nonsecretory MM, after stem cell, then thalidomide plus prednisolone, has relapsed & just started Revlimid plus dex. Wondering if anyone with non-sec MM is going down this track. Maureen

]]> By: Beacon Staff http://www.myelomabeacon.com/news/2010/07/28/higher-quality-response-to-revlimid-dexamethasone-combination-yields-better-prognosis-for-relapsed-and-refractory-multiple-myeloma-patients/comment-page-1/#comment-12344 Beacon Staff Thu, 29 Jul 2010 14:34:45 +0000 http://www.myelomabeacon.com/?p=9487#comment-12344 Dear Nick, The researchers used the European Group for Blood and Marrow Transplantation criteria and the International Myeloma Working Group uniform response criteria to assess the response to treatment. Complete response was defined as having no M-protein detectable by immunofixation in the serum and urine, disappearance of any soft tissue plasmacytomas, and less than 5 percent plasma cells in the bone marrow. Very good partial response was defined as having M-protein detectable by immunofixation but not on electrophoresis or a more than 90 percent reduction in serum M-protein level, and a urine M-protein level lower than 100mg/24 hours. Partial response was defined as having a more than 50 percent reduction of serum M-protein and a reduction in 24-hour urinary M-protein by more than 90 percent or lower than 200mg/24 hours. Dear Nick,

The researchers used the European Group for Blood and Marrow Transplantation criteria and the International Myeloma Working Group uniform response criteria to assess the response to treatment.

Complete response was defined as having no M-protein detectable by immunofixation in the serum and urine, disappearance of any soft tissue plasmacytomas, and less than 5 percent plasma cells in the bone marrow.

Very good partial response was defined as having M-protein detectable by immunofixation but not on electrophoresis or a more than 90 percent reduction in serum M-protein level, and a urine M-protein level lower than 100mg/24 hours.

Partial response was defined as having a more than 50 percent reduction of serum M-protein and a reduction in 24-hour urinary M-protein by more than 90 percent or lower than 200mg/24 hours.

]]> By: Sid Hider http://www.myelomabeacon.com/news/2010/07/28/higher-quality-response-to-revlimid-dexamethasone-combination-yields-better-prognosis-for-relapsed-and-refractory-multiple-myeloma-patients/comment-page-1/#comment-12340 Sid Hider Thu, 29 Jul 2010 14:10:41 +0000 http://www.myelomabeacon.com/?p=9487#comment-12340 Encouraging results. Are similar results being seen in the Rev-lite clinical trial or is it too early to reach a conclusion? Surely a trend can be seen. Rev-lite is using 15mg Lenalidomide (Revlimid) and 20mg Decadron (dexamethasone). The Rev-lite trial is to see if the lower dose is still effective and if less side effects occur. Sid Hider Encouraging results.
Are similar results being seen in the Rev-lite clinical trial or is it too early to reach a conclusion? Surely a trend can be seen.
Rev-lite is using 15mg Lenalidomide (Revlimid) and 20mg Decadron (dexamethasone).
The Rev-lite trial is to see if the lower dose is still effective and if less side effects occur.
Sid Hider

]]> By: Nick Argent http://www.myelomabeacon.com/news/2010/07/28/higher-quality-response-to-revlimid-dexamethasone-combination-yields-better-prognosis-for-relapsed-and-refractory-multiple-myeloma-patients/comment-page-1/#comment-12332 Nick Argent Thu, 29 Jul 2010 10:37:34 +0000 http://www.myelomabeacon.com/?p=9487#comment-12332 What measure has been used to determine whether or not there has been a significant beneficial response to the treatment protocol ? What measure has been used to determine whether or not there has been a significant beneficial response to the treatment protocol ?

]]>