With you as an example, your total IgA is 3580 mg/dL and the proportion of your IgA that is secreted by your myeloma cells is 1940 mg/dL.
But, be careful, for patients with IgA myeloma, it is especially hard to accurately define the "M-spike", i.e. the portion of IgA produced by your myeloma cells, primarily because the IgA immunoglobulin is about the same "size" as other normal proteins in your blood. There are even somewhat ridiculous times when a lab comes back with an IgA of 3000 mg/dL and an "M-spike" of 3100 mg/dL of IgA lambda, or some such thing. This is obviously a limit of the current technology.
Multiple Myeloma Clinic, The Ohio State University
Dr. Craig Hofmeister
- Name: Craig C. Hofmeister, M.D.
If your myeloma was making a monoclonal IgA antibody at initial diagnosis, I would be surprised if you did not have an M spike with an IgA level of 1640 mg/dL. The upper limits of normal for serum IgA is typically in the 400 range.
I would clarify this with your doctor and, if necessary, repeat the testing. Good luck to you!
University of North Carolina at Chapel Hill
Any advice provided in these postings is based on a very limited amount of information. There is no substitute for the care of your oncologist/hematologist. Therefore, all suggestions should be discussed with your treating physician. None of the comments presented here are meant to replace the evaluation of a patient by a knowledgeable physician.
Dr. Peter Voorhees
- Name: Peter Voorhees, M.D.
Beacon Medical Advisor
My question is: After reading the thread, am I to believe that his M-spike is 1300 mg? Is that possible?