This is an excellent question. In general, the immunophenotype of myeloma (e.g. IgG vs IgA) is no longer considered to be a major factor when determining prognosis.The cytogenetics of the myeloma calls are far more important. Cytogenetics should be performed on the diagnostic bone marrow for all newly diagnosed patients to determine prognosis and assist in treatment decisions. Cytogenetic findings which predict a more aggressive disease include: del 13, del 17, t (4;14), t (11;14), t (14;16) and 1q21amplification].
University of Washington & Fred Hutchinson Cancer Research Center
Any advice provided in these postings is based on a very limited amount of information. There is no substitute for the care of your oncologist/hematologist. Therefore, all suggestions should be discussed with your treating physician. None of the comments presented here are meant to replace the evaluation of a patient by a knowledgeable physician.
Dr. Edward Libby
- Name: Edward Libby, M.D.
Beacon Medical Advisor